The Colts added three Adam Vinatieri field goals from 37, 43 and 40 yards out along with a 9-yard touchdown pass to running back Trent Richardson off a shovel pass from Luck.
Indianapolis’ final points came on a safety when outside linebacker Robert Mathis sacked Texans quarterback Case Keenum, forcing a fumble that was recovered in the end zone by Houston offensive tackle Duane Brown.
On the play, Mathis set franchise records for career sacks with 108 and single season mark with 16.5. It was also marked his 16.5th career sack against the Texans, which is his most against any opponent.
The Colts defense took its cue from Mathis, limiting Houston to 12 first downs and 239 yards in total offense and forcing a pair of interceptions by cornerback Darius Butler. Butler very nearly missed getting his third interception midway through the third quarter.
A 49-yard field goal by placekicker Randy Bullock with 1:46 left in the second quarter accounted for all of the Texans’ points.
Keenum completed 18-of-34 passes for 168 yards and had the two interceptions. Running back Ben Tate netted a team-high 72 yards rushing in 16 carries to pace Houston’s offensive effort.
Wide receiver Andre Johnson, who had caused Indianapolis problems in the first meeting of the two teams this season, was limited to four catches for 18 yards.
The Colts defense came up with four sacks, one each by Mathis, safety Antoine Bethea, outside linebacker Erik Walden and rookie outside linebacker Bjoern Werner.
Luck connected on 19-of-32 passes for 180 yards and two touchdowns while rushing for 29 yards in five carries. He was also intercepted once and sacked once.
Richardson had his best day running the ball since joining the Colts, picking up 64 yards in 19 carries. He also caught four passes for 45 yards and a TD.
Wide receiver T.Y. Hilton hauled in eight passes for 78 yards while Whalen had his best day ever with four catches for 45 yards and a touchdown. He also averaged 22.3 yards on three punt returns, including a 51-yard effort that set up one of Vinatieri’s field goals.