Rushville Republican

News

February 25, 2014

Innovation could detect real-time effectiveness of cancer therapies

WEST LAFAYETTE - Oncologists and cancer patients could improve the results of drug therapies by making real-time decisions about treatment options using an innovation developed by a researcher in Purdue University’s College of Pharmacy.

Laurie L. Parker, assistant professor of medicinal chemistry and molecular pharmacology, is developing a method to detect if cancer-inhibiting drugs are entirely blocking the activity of enzymes, called kinases, in tumor cells. Several kinases are linked to cancer development. If a drug therapy only partially blocks kinase activity, the cells that survive could become a stronger tumor and develop a resistance to the drug.

“Currently, the only way doctors and patients learn if kinase activity is being blocked is by watching and waiting. Sometimes it takes months or years before signs of resistance are visible as the tumor regrows,” Parker said. “By the time it is detected, the relapsed tumor can’t be treated with that drug anymore.”

Parker and her graduate students created a method that works like a search engine by taking a lot of information about what a particular kinase looks for in a substrate, or the protein it acts upon. The technology narrows the information to a shortlist of traits, including being acted upon by only one kinase and providing the signal that the test seeks.

“The test uses the ‘artificial’ substrate we develop as a decoy, introducing it into the tumor cell and tricking the kinase into acting on it. If the kinase’s function is effectively blocked, we don’t see this action. Cancer drug dosages could be monitored and adjusted based on the test,” she said. “It also provides a general process to design a version of this pharmacodynamics test for virtually any kinase. It can be used for different cancer types and treatment strategies.”

Parker’s work also could benefit pharmaceutical companies as they complete initial drug screening and clinical trials.

Text Only
News
  • How to deal with nuisance wild animals Most people enjoy watching wildlife and sometimes even interacting with critters on occasion. One of my favorite activities is keeping the bird feeder well supplied and seeing Hoosier song birds up close and personal. Sometimes there are situations w

    April 22, 2014

  • Briefs Obituaries Marvin Cox, 67 Larry Dean Maupin, 68 Michael Tungate, 60 Thanks! The Rushville Republican thanks the following persons for their subscription to and support of this newspaper: John Owen Alan Amos Events Not-for-profits may submit upcoming

    April 22, 2014

  • 1 nws rv 042214 dark aisles Library continues 'It's overdue, renew' campaign Since the Rushville Public Library opened its doors in 1910, the library has been through changes. The original library was a two-room facility located in the county courthouse. In the late 1920's, a combination of public and private monies funded th

    April 22, 2014 2 Photos

  • 1 fd glenwood 042214 pic Improvements made to Glenwood Community Center Thanks in large part to a Rush County Community Foundation Grant (RCCFG), the Glenwood Community Center recently had new windows installed. The center was built in 1970 and has served the rural community since that time as a meeting site for the town

    April 22, 2014 1 Photo

  • 1 fd comms 042214 pic 'Chicken Ordinance' returned to BZA unsigned Meeting for the second time in their new home, the Assembly Room of the county courthouse, the county commissioners needed the additional space as a result of the number of those in attendance Monday. A number of those on hand came to voice their con

    April 22, 2014 1 Photo

  • 2 nws-rv-042214-Mohr candidacy pic Gerald Mohr announces candidacy for County Council District One Gerald Mohr is married to Anita (Smith) Mohr and they are parents to Brian (Katie) Mohr and Brett (Andrea) Mohr. They are proud grandparents to Hailey, Spencer, Carter and Asha Mohr. Gerald started his career in Rush County upon graduation from India

    April 22, 2014 1 Photo

  • Meal time request, 'May I be excused from the table please?' In a day and age filled with fast food dining and other meals consumed on the living room coffee table, I grew up in a different time. My mother and father were rigid about a number of things, but few things had my attention more than at meal times.

    April 22, 2014

  • sch-rv041814-school lunch pic More than half of local students get lunch assistance The share of students at Greensburg Community Schools who get free and reduced lunches has spiked by about a third in the last five years. Fifty-one percent of Greensburg students get help through the federal school lunch program, according to the In

    April 18, 2014 1 Photo

  • Purdue events calendar Events in this calendar, plus many others, are listed in Purdue's online calendar at http://calendar.purdue.edu ENTERTAINMENT • April 17. 7:30 p.m. Loeb Playhouse. Brad Mehldau jazz piano trio, presented by Purdue Convocations. Ticket holders are in

    April 18, 2014

  • Court appearances near for park vandals As the result of a news article in the March 14 edition of the Rushville Republican, officers from the Rushville Police Department arrested two individuals in connection with vandalism in South Veterans Memorial Park one day after the news article hi

    April 18, 2014